https://unilogia.su/index.php?action=history&feed=atom&title=Active_chromatin_sequenceActive chromatin sequence - История изменений2026-04-09T00:37:00ZИстория изменений этой страницы в викиMediaWiki 1.44.2https://unilogia.su/index.php?title=Active_chromatin_sequence&diff=802&oldid=prevAdmin: 1 версия импортирована2025-11-13T17:59:41Z<p>1 версия импортирована</p>
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</table>Adminhttps://unilogia.su/index.php?title=Active_chromatin_sequence&diff=801&oldid=prevru>John of Reading: /* top */Typo fixing, replaced: can caused → can cause2024-01-06T15:21:42Z<p><span class="autocomment">top: </span>Typo fixing, replaced: can caused → can cause</p>
<p><b>Новая страница</b></p><div>{{Short description|Region of DNA in a eukaryotic chromosome}}<br />
[[File:Heterochromatin vs. euchromatin.svg|thumb|Heterochromatin vs. euchromatin]]<br />
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An '''active chromatin sequence''' (ACS) is a region of [[DNA]] in a [[eukaryote|eukaryotic]] [[chromosome]] in which [[histone]] modifications such as [[acetylation]] lead to exposure of the [[DNA sequence]] thus allowing binding of [[transcription factors]] and [[Transcription (genetics)|transcription]] to take place. Active chromatin may also be called [[euchromatin]]. ACSs may occur in non-expressed gene regions which are assumed to be "poised" for [[gene transcription|transcription]]. The sequence once exposed often contains a promoter to begin transcription. At this site [[acetylation]] or [[methylation]] can take place causing a conformational change to the chromatin. At the active chromatin sequence site deacetylation can cause the gene to be repressed if not being expressed.<br />
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==See also==<br />
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[[Chromatin]]<br />
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==References==<br />
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*{{cite journal |vauthors =Sabo PJ, Humbert R, Hawrylycz M |title=Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue=13 |pages=4537–42 |date=March 2004 |pmid=15070753 |pmc=384782 |doi=10.1073/pnas.0400678101 |bibcode=2004PNAS..101.4537S |display-authors=etal|doi-access=free }}<br />
*{{cite journal|pmc=551575 | pmid=15706033 | doi=10.1101/gad.1272505 | volume=19 | issue=5 | title=Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping |vauthors=Roh TY, Cuddapah S, Zhao K | journal=Genes Dev | pages=542–52| year=2005 }}<br />
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[[Category:Genetics]]<br />
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{{genetics-stub}}</div>ru>John of Reading