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gaaa The '''Britten–Davidson''' model,<ref>{{cite journal | doi=10.1126/science.165.3891.349 | author=Britten R. and E.H. Davidson | title=Gene regulation for higher cells: a theory | journal=Science | volume=165 | pages=349–57 | pmid=5789433 | year=1969 | issue=3891| bibcode=1969Sci...165..349B }}</ref><ref>{{cite web| title=Britten-Davidson model for unit of transcription| publisher=biocyclopedia.com| access-date=2013-08-14| url=http://www.biocyclopedia.com/index/genetics/regulation_of_gene_expression_a_variety_of_mechanisms_in_eukaryotes/brittendavidson_model_for_unit_of_transcription.php}}</ref> also known as the gene-battery model,<ref>{{cite book| title=Genetics Classical to Modern| last=Gupta| first=P.K.| publisher=Rastogi Publications| year=2007| page=657}}</ref> is a hypothesis for the regulation of [[protein synthesis]] in [[eukaryote]]s. Proposed by [[Roy John Britten]] and [[Eric H. Davidson]] in 1969, the model postulates four classes of [[DNA]] sequence: an integrator gene, a producer gene, a receptor site, and a sensor site. The sensor site regulates the integrator gene, responsible for synthesis of activator RNA. The integrator gene cannot synthesize activator RNA unless the sensor site is activated. Activation and deactivation of the sensor site is done by external stimuli, such as [[Hormone|hormones]]. The activator RNA then binds with a nearby receptor site, which stimulates the synthesis of [[mRNA]] at the [[structural gene]].<br />
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This theory would explain how several different integrators could be concurrently synthesized, and would explain the pattern of [[repetitive DNA]] sequences followed by a unique [[DNA]] sequence that exists in [[gene]]s.<ref>{{cite book| title=Genetics Classical to Modern| last=Gupta| first=P.K.| publisher=Rastogi Publications| year=2007| page=657}}</ref><br />
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==See also==<br />
*[[Transcriptional regulation]]<br />
*[[Operon]]<br />
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==References==<br />
{{reflist}}<br />
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{{DEFAULTSORT:Britten-Davidson model}}<br />
[[Category:Genetics]]<br />
[[Category:Biology theories]]<br />
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