https://unilogia.su/index.php?action=history&feed=atom&title=Genetic_imbalance 2026-04-08T22:32:12Z История изменений этой страницы в вики MediaWiki 1.44.2 https://unilogia.su/index.php?title=Genetic_imbalance&diff=1018&oldid=prev 2025-11-13T18:01:18Z

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Admin https://unilogia.su/index.php?title=Genetic_imbalance&diff=1017&oldid=prev 2022-09-27T00:40:14Z

<p>Removed {{<a href="/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Cleanup&amp;action=edit&amp;redlink=1" class="new" title="Шаблон:Cleanup (страница не существует)">Cleanup</a>}} tag</p> <p><b>Новая страница</b></p><div>{{Multiple issues|<br /> {{More citations needed|date=June 2022}}<br /> {{No footnotes|date=June 2022}}<br /> }}<br /> &#039;&#039;&#039;[[Genetics|Genetic]] imbalance&#039;&#039;&#039; is to describe situation when the [[genome]] of a cell or organism has more copies of some genes than other genes due to [[chromosomal]] [[rearrangement reaction|rearrangements]] or [[aneuploidy]].<br /> Changes in [[gene dosage]], the number of times a given gene is present in the [[cell nucleus]], can create a genetic imbalance.<br /> <br /> == Effects ==<br /> This imbalance in gene dosage alters the amount of a particular [[protein]] relative to all other proteins, and this alternation in the relative amounts of protein can have a variety of [[phenotypic]] effects. These effects are depending on how the proteins function and how critical the maintenance of a precise ratio of proteins is to the [[wikt:survival|survival]] of the organism.<br /> <br /> Diminishing the dosage of most genes produces no obvious change in [[phenotype]]. For some genes the phenotypic consequences of a decrease in gene dosage are noticeable but not catastrophic. For example, &#039;&#039;Drosophila&#039;&#039; containing only one copy of the [[wild type]] Notch gene has visible wing abnormalities but otherwise seems to function normally. For some rare genes, the normal [[diploid]] level of [[gene expression]] is essential to individual survival; fewer than two copies of such a gene results in [[lethality]]. In [[Drosophila]], a single dose of the locus known as Triplolethal is in an otherwise diploid individual.<br /> <br /> Although a single dose of any gene may not cause substantial harm to the individual, the genetic imbalance resulting from a single dose of many genes at the same time can be lethal. Humans, for example, cannot survive, even as [[heterozygotes]], with [[deletion (genetics)|deletion]]s that remove more than about 3% of any part of their [[haploid]] [[genome]].<br /> <br /> == References ==<br /> {{Reflist}}<br /> {{refbegin}}<br /> * {{cite book |vauthors=Hartwell L, Hood L, Goldberg ML, Reynolds AE, Silver LM, Veres R | title = Genetics: from genes to genomes | edition = Second | publisher = McGraw-Hill Higher Education | location = Boston | year = 2004 | isbn = 0-07-291930-2 | url =https://archive.org/details/genetics00|url-access=registration }}<br /> {{refend}}<br /> <br /> [[Category:Genetics]]</div>

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