Admin: 1 версия импортирована

2025-11-13T17:59:19Z

1 версия импортирована

← Предыдущая версия		Версия от 17:59, 13 ноября 2025
(нет различий)

ru>Monkbot: Monkbot/task 21: Replace page(s) with article-number;

2025-09-30T07:40:37Z

Monkbot/task 21: Replace page(s) with article-number;

Новая страница

{{Short description|Imaging Genetics}}
'''Imaging genetics''' refers to the use of anatomical or physiological imaging technologies as [[phenotypic]] [[assays]] to evaluate [[Genetics|genetic]] variation. Scientists that first used the term imaging genetics were interested in how genes influence [[psychopathology]] and used [[functional neuroimaging]] to investigate genes that are expressed in the [[brain]] (neuroimaging genetics).<ref>{{Cite journal
| author1 = Hariri, A. R.
| author2 = Drabant, E.M.
| author3 = Weinberger, D. R.
| date=May 2006
| title = Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing
| issue = 10
| pages = 888–897
| journal = [[Biological Psychiatry]]
| pmid = 16442081
| volume = 59
| doi = 10.1016/j.biopsych.2005.11.005
| s2cid = 22972473
}}</ref>

Imaging genetics uses research approaches in which genetic information and [[fMRI]] data in the same subjects are combined to define neuro-mechanisms linked to genetic variation.<ref>{{cite journal|last=Hariri|author2=Weinberger|title=Imaging Genomics|journal=British Medical Bulletin|volume=65|pages=259–270|doi=10.1093/bmb/65.1.259|pmid=12697630|year=2003|doi-access=}}</ref> With the images and genetic information, it can be determined how individual differences in [[single nucleotide polymorphisms]], or SNPs, lead to differences in brain wiring structure, and intellectual function.<ref>{{cite journal|last=Thompson|journal=Imaging Genetics|year=2012|url=http://www.loni.ucla.edu/~thompson/IG/IG.html|title=Archived copy|access-date=2012-12-11|archive-url=https://web.archive.org/web/20120408122533/http://www.loni.ucla.edu/~thompson/IG/IG.html|archive-date=2012-04-08}}</ref> Imaging genetics allows the direct observation of the link between genes and brain activity in which the overall idea is that common variants in SNPs lead to common diseases.<ref>{{cite journal|last=Chi|title=Hit or Miss?|journal=Nature|year=2009|volume=461|issue=8|pages=712–714|doi=10.1038/461712a|pmid=19812647|doi-access=free}}</ref> A neuroimaging [[phenotype]] is attractive because it is closer to the biology of genetic function than illnesses or cognitive phenotypes.<ref>{{cite journal|last=Meyer-Lindenberg|title=The Future of fMRI and Genetics Research|journal=NeuroImage|year=2012|volume=62|issue=2|pages=1286–1292|doi=10.1016/j.neuroimage.2011.10.063|pmid=22051224|s2cid=214038}}</ref>

== Alzheimer's disease ==

By combining the outputs of the polygenic and neuro-imaging within a linear model, it has been shown that genetic information provides additive value in the task of predicting [[Alzheimer's disease]] (AD).<ref>{{cite book|last=Filipovych|author2=Gaonkar, Davatzikos|title=2012 Second International Workshop on Pattern Recognition in NeuroImaging |chapter=A Composite Multivariate Polygenic and Neuroimaging Score for Prediction of Conversion to Alzheimer's Disease |date=2012 |pages=105–108|doi=10.1109/PRNI.2012.9 |pmid=24899230 |pmc=4041795 |isbn=978-1-4673-2182-2 }}</ref> AD traditionally has been considered a disease marked by neuronal cell loss and widespread gray matter atrophy and the apolipoprotein E allele ([[APOE4]]) is a widely confirmed genetic risk factor for late-onset AD.<ref name=Braskie>{{cite journal|last=Braskie|first=Meredith N.|author2=Jahanshad, Neda|author3=Stein, Jason L.|author4=Barysheva, Marina|author5=McMahon, Katie L.|author6=de Zubicaray, Greig I.|author7=Martin, Nicholas G.|author8=Wright, Margaret J.|author9=Ringman, John M.|author10=Toga, Arthur W.|author11=Thompson, Paul M.|title=Common Alzheimer's Disease Risk Variant within the CLU Gene Affects White Matter Microstructure in Young Adults|journal=The Journal of Neuroscience|year=2011|volume=31|issue=18|pages=6764–6770|doi=10.1523/jneurosci.5794-10.2011|pmid=21543606|pmc=3176803}}</ref>

Another gene risk variant is associated with Alzheimer's, which is known as the [[CLU gene]] risk variant. The CLU gene risk variant showed a distinct profile of lower white matter integrity that may increase vulnerability to developing AD later in life.<ref name=Braskie /> Each CLU-C allele was associated with lower FA in frontal, temporal, parietal, occipital, and subcortical white matter.<ref name=Braskie /> Brain regions with lower FA included corticocortical pathways previously demonstrated to have lower FA in AD patients and APOE4 carriers.<ref name=Braskie /> CLU-C related variability found here might create a local vulnerability important for disease onset.<ref name=Braskie /> These effects are remarkable as they already exist early in life and are associated with a risk gene that is very prevalent (~36% of Caucasians carry two copies of the risk conferring genetic variant CLU-C.) <ref name=Braskie />
Quantitative mapping of structural brain differences in those at genetic risk of AD is crucial for evaluating treatment and prevention strategies. If the risk for AD is identified, appropriate changes in lifestyle may limit the apprehension of AD; exercise and body mass index-have an effect on brain structure and the level of brain atrophy <ref name=Braskie />

=== Biomarkers and Alzheimer's spectrum ===

If suitable biomarkers are found and applied in clinical use, we will be able to give the diagnosis of the AD spectrum at an even earlier stage.<ref name=Takeda>{{cite journal|title=Biomarkers and Alzheimer's Spectrum|journal=Psychiatry and Clinical Neurosciences|author=Takeda, Masatoshi|year=2011|volume=65|issue=2|pages=115–120|doi=10.1111/j.1440-1819.2011.02197.x|pmid=21414086|doi-access=free}}</ref> In the proposal, the AD spectrum is divided into the three stages (i) the preclinical stage; (ii) mild cognitive impairment; and (iii) clinical AD.<ref name=Takeda /> In the preclinical stage, only changes in a specific biomarker are observed with neither cognitive impairment nor clinical signs of AD. The mild cognitive impairment stage may include those showing biomarker changes as well as mild cognitive decline but no clinical signs and symptoms of AD. AD is diagnosed in patients with biomarker changes and clinical signs and symptoms of AD. This concept will promote understanding of the continuous transition from preclinical stage to AD via mild cognitive impairment, in which biomarkers can be utilized to discriminate and clearly define each stage of the AD spectrum. The new criteria will promote earlier detection of the subjects who will develop AD in later life, and also to initiate intervention aiming for the prevention of AD.

== Future ==

Imaging genetics must develop methods that will allow relating the effects of a large number of genetic variants on equally multi-dimensional neuroimaging phenotypes.<ref name=Bedenbender>{{cite journal|last=Bedenbender |author2=Paulus, Krach |author3=Pyka, Sommer|title=Functional Connectivity Analyses in Imaging Genetics: considerations on Methods and Data Interpretation|journal=PLOS ONE|year=2011|volume=6|issue=12|doi=10.1371/journal.pone.0026354|article-number=e26354|pmid=22220190|pmc=3248388|bibcode=2011PLoSO...626354B |doi-access=free }}</ref> Additionally, the field of imaging epigenetics is emerging with particular relevance, for example, to the understanding of intergenerational transmission of trauma-related psychopathology and related disturbances of maternal care.<ref>{{cite journal|author1=Schechter DS|author2=Moser DA|author3=Paoloni-Giacobino A|author4=Stenz A|author5=Gex-Fabry M|author6=Aue T|author7=Adouan W|author8=Cordero MI|author9=Suardi F|author10=Manini A|author11=Sancho Rossignol A|author12=Merminod G|author13=Ansermet F|author14=Dayer AG|author15=Rusconi Serpa S|year=2015|title=Methylation of NR3C1 is related to maternal PTSD, parenting stress and maternal medial prefrontal cortical activity in response to child separation among mothers with histories of violence exposure|journal=Frontiers in Psychology|volume=6|page=690|doi=10.3389/fpsyg.2015.00690|pmid=26074844|url=https://archive-ouverte.unige.ch/unige:76406/ATTACHMENT01|pmc=4447998|doi-access=free|access-date=2019-04-07|archive-date=2020-11-07|archive-url=https://web.archive.org/web/20201107125034/https://archive-ouverte.unige.ch/files/downloads/0/0/0/7/6/4/0/6/unige_76406_attachment01.pdf|url-status=live}}</ref>

== Problems ==
Medication, hospitalization history, or associated behaviors ranging such as smoking can affect imaging.<ref name=Bedenbender />

==Notes==
{{Reflist}}

==External links==
* [http://www.imaginggenetics.uci.edu International Imaging Genetics Conference website] {{Webarchive|url=https://web.archive.org/web/20120128012844/http://www.imaginggenetics.uci.edu/ |date=2012-01-28 }}.

{{Neuroscience}}
{{Psychiatry}}

[[Category:Genetics]]
[[Category:Neuroscience]]

Imaging genetics - История изменений

Admin: 1 версия импортирована

ru>Monkbot: Monkbot/task 21: Replace page(s) with article-number;