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{{Short description|Failure to separate properly during cell division}}
[[File:Nondisjunction Diagrams.svg|600px|thumb|{{olist
|[[Meiosis I]]
|[[Meiosis II]]
|[[Fertilization]]
|[[Zygote]]
}} The left image at the blue arrow is nondisjunction taking place during meiosis II. The right image at the green arrow is nondisjunction taking place during meiosis I. Nondisjunction is when chromosomes fail to separate normally resulting in a gain or loss of chromosomes.]]
'''Nondisjunction''' is the failure of [[homologous chromosomes]] or [[sister chromatids]] to separate properly during [[cell division]] ([[mitosis]]/[[meiosis]]). There are three forms of nondisjunction: failure of a pair of [[homologous chromosomes]] to separate in [[meiosis I]], failure of sister chromatids to separate during [[meiosis II]], and failure of sister chromatids to separate during [[mitosis]].<ref name=Snustad>{{cite book|last=Simmons|first=D. Peter Snustad, Michael J.|title=Principles of genetics|year=2006|publisher=Wiley|location=New York, NY [u.a.]|isbn=978-0-471-69939-2|edition=4th|url-access=registration|url=https://archive.org/details/principlesofgene04edsnus}}</ref><ref name="Nelson">{{cite book|last1=Bacino|first1=C.A.|last2=Lee|first2=B.|editor1-last=Kliegman|editor1-first=R.M.|editor2-last=Stanton|editor2-first=B.F.|editor3-last=St. Geme|editor3-first=J.W.|editor4-last=Schor|editor4-first=N.F.|editor5-last=Behrman|editor5-first=R.E.|title=Nelson Textbook of Pediatrics, 19th Edition|date=2011|publisher=Saunders|location=Philadelphia|isbn=978-1-4377-0755-7|pages=394–413|edition=19th|chapter=Chapter 76: Cytogenetics}}</ref><ref name=Strachan>{{cite book|last=Strachan|first=Tom|title=Human molecular genetics|year=2011|publisher=Garland Science|location=New York|isbn=978-0-8153-4149-9|edition=4th|author2=Read, Andrew }}</ref> Nondisjunction results in daughter cells with abnormal chromosome numbers ([[aneuploidy]]).

[[Calvin Bridges]] and [[Thomas Hunt Morgan]] are credited with discovering nondisjunction in ''[[Drosophila melanogaster]]'' sex chromosomes in the spring of 1910, while working in the Zoological Laboratory of Columbia University.<ref>{{cite book|title=Sex-Linked Inheritance in Drosophila|date=August 31, 2012|publisher=Ulan Press|pages=10–11|url=https://www.gutenberg.org/files/34368/34368-h/34368-h.htm|author=Thomas Hunt Morgan}}</ref> Proof of the [[chromosome]] theory of heredity emerged from these early studies of chromosome non-disjunction.<ref>{{cite journal |vauthors=Bridges CB |title=Non-Disjunction as Proof of the Chromosome Theory of Heredity |journal=Genetics |volume=1 |issue=1 |pages=1–52 |date=January 1916 |pmid=17245850 |pmc=1193653 |doi=10.1093/genetics/1.1.1 |url=}}</ref>

==Types==
In general, nondisjunction can occur in any form of cell division that involves ordered distribution of chromosomal material. Higher animals have three distinct forms of such cell divisions: [[Meiosis I]] and [[meiosis II]] are specialized forms of cell division occurring during generation of [[gametes]] (eggs and sperm) for sexual reproduction, [[mitosis]] is the form of cell division used by all other cells of the body.{{cn|date=May 2024}}

=== Meiosis II ===
Ovulated eggs become arrested in metaphase II until [[fertilization]] triggers the second meiotic division.<ref name=Nagaoka>{{cite journal|last=Nagaoka|first=SI|author2=Hassold, TJ |author3=Hunt, PA |title=Human aneuploidy: mechanisms and new insights into an age-old problem.|journal=Nature Reviews Genetics|date=Jun 18, 2012|volume=13|issue=7|pages=493–504|pmid=22705668|doi=10.1038/nrg3245|pmc=3551553}}</ref> Similar to the segregation events of [[mitosis]], the pairs of sister [[chromatids]] resulting from the separation of bivalents in [[meiosis I]] are further separated in [[anaphase]] of [[meiosis II]]. In oocytes, one sister chromatid is segregated into the second polar body, while the other stays inside the egg. During [[spermatogenesis]], each meiotic division is symmetric such that each primary [[spermatocyte]] gives rise to 2 secondary spermatocytes after meiosis I, and eventually 4 [[spermatid]]s after meiosis II. Meiosis II-nondisjunction may also result in [[aneuploidy]] syndromes, but only to a much smaller extent than do [[Chromosome segregation|segregation]] failures in meiosis I.<ref name=Jones>{{cite journal|last=Jones|first=K. T.|author2=Lane, S. I. R. |title=Molecular causes of aneuploidy in mammalian eggs|journal=Development|date=27 August 2013|volume=140|issue=18|pages=3719–3730|doi=10.1242/dev.090589|pmid=23981655|doi-access=free}}</ref>

[[File:Mitotic nondisjunction.png|600px|thumb|'''Nondisjunction of sister chromatids during mitosis:''' 
''Left:'' Metaphase of mitosis. Chromosome line up in the middle plane, the mitotic spindle forms and the kinetochores of sister chromatids attach to the microtubules. 
''Right:'' Anaphase of mitosis, where sister chromatids separate and the microtubules pull them in opposite directions. 
The chromosome shown in ''red'' fails to separate properly, its sister chromatids stick together and get pulled to the same side, resulting in mitotic nondisjunction of this chromosome. ]]

=== Mitosis ===
Division of [[Somatic (biology)|somatic]] cells through mitosis is preceded by replication of the genetic material in [[S phase]]. As a result, each chromosome consists of two sister [[chromatids]] held together at the [[centromere]]. In the [[anaphase]] of [[mitosis]], sister [[chromatids]] separate and migrate to opposite cell poles before the cell divides. Nondisjunction during [[mitosis]] leads to one daughter receiving both sister [[chromatids]] of the affected chromosome while the other gets none.<ref name=Nelson /><ref name=Strachan /> This is known as a [[chromatin bridge]] or an anaphase bridge. Mitotic nondisjunction results in somatic [[mosaicism]], since only daughter cells originating from the cell where the nondisjunction event has occurred will have an abnormal number of [[chromosomes]].<ref name=Strachan/> Nondisjunction during mitosis can contribute to the development of some forms of [[cancer]], e.g., [[retinoblastoma]] (see below).<ref name=Scriver>{{cite book|last=eds|first=Charles R. Scriver ... []|title=The online metabolic & molecular bases of inherited disease|year=2005|publisher=McGraw-Hill|location=New York|isbn=978-0-07-913035-8|edition=8th|display-authors=etal }}</ref> Chromosome nondisjunction in mitosis can be attributed to the inactivation of [[topoisomerase II]], [[condensin]], or [[separase]].<ref>{{cite journal|last=Quevedo|first=O|author2=García-Luis, J |author3=Matos-Perdomo, E |author4=Aragón, L |author5= Machín, F |title=Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2.|journal=PLOS Genetics|year=2012|volume=8|issue=2|article-number=e1002509|pmid=22363215 |doi=10.1371/journal.pgen.1002509 |pmc=3280967|doi-access=free}}</ref> Meiotic nondisjunction has been well studied in ''[[Saccharomyces cerevisiae]]''. This yeast undergoes mitosis similarly to other [[eukaryotes]]. Chromosome bridges occur when sister chromatids are held together post replication by DNA-DNA topological entanglement and the [[cohesion (chemistry)|cohesion]] complex.<ref>{{cite journal|last=Vaahtokari|first=A|author2=Aberg, T |author3=Thesleff, I |title=Apoptosis in the developing tooth: association with an embryonic signaling center and suppression by EGF and FGF-4.|journal=Development|date=Jan 1996|volume=122|issue=1|pages=121–9|doi=10.1242/dev.122.1.121|pmid=8565823}}</ref> During anaphase, [[cohesin]] is cleaved by separase.<ref>{{cite journal|last=Banks|first=P|title=Pulp changes after anterior mandibular subapical osteotomy in a primate model.|journal=Journal of Maxillofacial Surgery|date=Feb 1977|volume=5|issue=1|pages=39–48|pmid=0403247|doi=10.1016/s0301-0503(77)80074-x}}</ref> Topoisomerase II and condensin are responsible for removing [[catenation]]s.<ref>{{cite journal|last=Holm|first=C|author2=Goto, T |author3=Wang, JC |author4= Botstein, D |title=DNA topoisomerase II is required at the time of mitosis in yeast.|journal=Cell|date=Jun 1985|volume=41|issue=2|pages=553–63|pmid=2985283 |doi=10.1016/s0092-8674(85)80028-3|s2cid=715110}}</ref>

==Molecular mechanisms==

=== Central role of the spindle assembly checkpoint ===
The [[spindle assembly checkpoint]] (SAC) is a molecular safe-guarding mechanism that governs proper [[chromosome segregation]] in eukaryotic cells.<ref name=Sun>{{cite journal|last=Sun|first=S.-C.|author2=Kim, N.-H. |title=Spindle assembly checkpoint and its regulators in meiosis|journal=Human Reproduction Update|date=14 November 2011|volume=18|issue=1|pages=60–72|doi=10.1093/humupd/dmr044|pmid=22086113|doi-access=free}}</ref> SAC inhibits progression into anaphase until all homologous chromosomes (bivalents, or tetrads) are properly aligned to the [[spindle apparatus]]. Only then, SAC releases its inhibition of the [[anaphase promoting complex]] (APC), which in turn irreversibly triggers progression through anaphase.{{cn|date=May 2024}}

=== Sex-specific differences in meiosis ===
Surveys of cases of human aneuploidy syndromes have shown that most of them are maternally derived.<ref name=Nagaoka /> This raises the question: Why is female meiosis more error prone? The most obvious difference between female oogenesis and male spermatogenesis is the prolonged arrest of oocytes in late stages of [[prophase I]] for many years up to several decades. Male gametes on the other hand quickly go through all stages of meiosis I and II. Another important difference between male and female meiosis concerns the frequency of recombination between homologous chromosomes: In the male, almost all chromosome pairs are joined by at least one [[chromosomal crossover|crossover]], while more than 10% of human oocytes contain at least one bivalent without any crossover event. Failures of recombination or inappropriately located crossovers have been well documented as contributors to the occurrence of nondisjunction in humans.<ref name=Nagaoka />

=== Age-related loss of cohesin ties ===
Due to the prolonged arrest of human oocytes, weakening of cohesive ties holding together chromosomes and reduced activity of the SAC may contribute to maternal age-related errors in [[Chromosome segregation|segregation]] control.<ref name=Jones /><ref name=Eichenlaub>{{cite journal|last=Eichenlaub-Ritter|first=Ursula|title=Oocyte ageing and its cellular basis|journal=The International Journal of Developmental Biology|year=2012|volume=56|issue=10–11–12|pages=841–852|doi=10.1387/ijdb.120141ue|pmid=23417406|doi-access=free}}</ref> The [[cohesin]] complex is responsible for keeping together sister chromatids and provides binding sites for spindle attachment. Cohesin is loaded onto newly replicated chromosomes in [[oogonia]] during fetal development. Mature [[oocytes]] have only limited capacity for reloading cohesin after completion of [[S phase]]. The prolonged arrest of human oocytes prior to completion of meiosis I may therefore result in considerable loss of cohesin over time. Loss of cohesin is assumed to contribute to incorrect [[microtubule]]-[[kinetochore]] attachment and chromosome segregation errors during meiotic divisions.<ref name = Jones />

==Consequences==
The result of this error is a cell with an imbalance of chromosomes. Such a cell is said to be [[aneuploid]]. Loss of a single chromosome (2n-1), in which the daughter cell(s) with the defect will have one chromosome missing from one of its pairs, is referred to as a [[monosomy]]. Gaining a single chromosome, in which the daughter cell(s) with the defect will have one chromosome in addition to its pairs is referred to as a [[trisomy]].<ref name=Strachan /> In the event that an aneuploidic gamete is fertilized, a number of syndromes might result.{{cn|date=May 2024}}

=== Monosomy ===
The only known survivable monosomy in humans is [[Turner syndrome]], where the affected individual is monosomic for the [[X chromosome]] (see below). Other monosomies are usually lethal during early fetal development, and survival is only possible if not all the cells of the body are affected in case of a [[mosaicism]] (see below), or if the normal number of chromosomes is restored via duplication of the single monosomic chromosome ("chromosome rescue").<ref name=Nelson />

==== Turner syndrome (X monosomy) (45, X0) ====
[[File:45,X.jpg|300px|thumb| '''Karyotype of X monosomy (Turner syndrome)''' This condition is characterized by the presence of '''only one X chromosome''' and no Y chromosome (see bottom right corner).]]

Complete loss of an entire X chromosome accounts for about half the cases of [[Turner syndrome]]. The importance of both X chromosomes during embryonic development is underscored by the observation that the overwhelming majority (>99%) of fetuses with only one X chromosome ([[karyotype]] 45, X0) are spontaneously aborted.<ref name =Avery/>

=== Autosomal trisomy ===
The term autosomal trisomy means that a chromosome other than the sex chromosomes X and Y is present in 3 copies instead of the normal number of 2 in diploid cells.{{cn|date=May 2024}}

====Down syndrome (trisomy 21)====
[[File:Down Syndrome Karyotype.png|300px|thumb| '''Karyotype of trisomy 21 (Down syndrome)''' 
Note that chromosome 21 is present in 3 copies, while all other chromosomes show the normal diploid state with 2 copies. Most cases of trisomy of chromosome 21 are caused by a nondisjunction event during meiosis I (see text).]]
[[Down syndrome]], a trisomy of chromosome 21, is the most common anomaly of chromosome number in humans.<ref name = Nelson/> The majority of cases result from nondisjunction during maternal meiosis I.<ref name = Avery>{{cite book|editor-last=Gleason|editor-first=H. William|editor2=Taeusch, Roberta A.|editor3=Ballard, Christine A.|title=Avery's diseases of the newborn|year=2005|publisher=W.B. Saunders|location=Philadelphia, Pa.|isbn=978-0-7216-9347-7|edition=8th}}</ref> Trisomy occurs in at least 0.3% of newborns and in nearly 25% of [[spontaneous abortions]]. It is the leading cause of pregnancy wastage and is the most common known cause of [[intellectual disability]].<ref>{{cite journal|last=Koehler|first=KE|author2=Hawley, RS |author3=Sherman, S |author4= Hassold, T |title=Recombination and nondisjunction in humans and flies.|journal=Human Molecular Genetics|year=1996|volume=5 Spec No|pages=1495–504|pmid=8875256|doi=10.1093/hmg/5.Supplement_1.1495 |doi-access=free}}</ref> It is well documented that [[advanced maternal age]] is associated with greater risk of meiotic nondisjunction leading to Down syndrome. This may be associated with the prolonged meiotic arrest of human oocytes potentially lasting for more than four decades.<ref name = Eichenlaub />

====Edwards syndrome (trisomy 18) and Patau syndrome (trisomy 13)====
Human autosomal trisomies compatible with live birth, other than [[Down syndrome]] (trisomy 21), are [[Edwards syndrome]] (trisomy 18) and [[Patau syndrome]] (trisomy 13).<ref name =Snustad /><ref name = Nelson/> Complete trisomies of other chromosomes are usually not viable and represent a relatively frequent cause of miscarriage. Only in rare cases of a [[mosaicism]], the presence of a normal cell line, in addition to the trisomic cell line, may support the development of a viable trisomy of the other chromosomes.<ref name = Nelson/>

=== Sex chromosome aneuploidy ===
The term ''sex chromosome aneuploidy'' summarizes conditions with an abnormal number of sex chromosomes, i.e., other than XX (female) or XY (male). Formally, X chromosome monosomy ([[Turner syndrome]], see above) can also be classified as a form of sex chromosome aneuploidy.{{cn|date=May 2024}}

==== Klinefelter syndrome (47, XXY) ====
[[Klinefelter syndrome]] is the most common sex chromosome aneuploidy in humans. It represents the most frequent cause of [[hypogonadism]] and [[infertility]] in men. Most cases are caused by nondisjunction errors in paternal meiosis I.<ref name = Nelson /> About eighty percent of individuals with this syndrome have one extra X chromosome resulting in the [[karyotype]] XXY. The remaining cases have either multiple additional sex chromosomes (48,XXXY; 48,XXYY; 49,XXXXY), mosaicism (46,XY/47,XXY), or structural chromosome abnormalities.<ref name= Nelson />

==== XYY Male (47, XYY) ====
The incidence of [[XYY syndrome]] is approximately 1 in 800–1000 male births. Many cases remain undiagnosed because of their normal appearance and fertility, and the absence of severe symptoms. The extra Y chromosome is usually a result of nondisjunction during paternal meiosis II.<ref name=Nelson />

==== Trisomy X (47,XXX) ====
[[Trisomy X]] is a form of sex chromosome aneuploidy where females have three instead of two X chromosomes. Most patients are only mildly affected by neuropsychological and physical symptoms. Studies examining the origin of the extra X chromosome observed that about 58–63% of cases were caused by nondisjunction in maternal meiosis I, 16–18% by nondisjunction in maternal meiosis II, and the remaining cases by post-zygotic, i.e., mitotic, nondisjunction.<ref name=Tartaglia>{{cite journal|last=Tartaglia|first=NR|author2=Howell, S |author3=Sutherland, A |author4=Wilson, R |author5= Wilson, L |title=A review of trisomy X (47,XXX).|journal=Orphanet Journal of Rare Diseases|date=May 11, 2010|volume=5|page=8|pmid=20459843 |doi=10.1186/1750-1172-5-8 |pmc=2883963 |doi-access=free }}</ref>

=== Uniparental disomy ===
[[Uniparental disomy]] denotes the situation where both chromosomes of a chromosome pair are inherited from the same parent and are therefore identical. This phenomenon most likely is the result of a pregnancy that started as a trisomy due to nondisjunction. Since most trisomies are lethal, the fetus only survives because it loses one of the three chromosomes and becomes disomic. Uniparental disomy of chromosome 15 is, for example, seen in some cases of [[Prader-Willi]] syndrome and [[Angelman syndrome]].<ref name = Avery/>

=== Mosaicism syndromes ===
[[Mosaicism]] syndromes can be caused by mitotic nondisjunction in early fetal development. As a consequence, the organism evolves as a mixture of cell lines with differing [[ploidy]] (number of chromosomes). Mosaicism may be present in some tissues, but not in others. Affected individuals may have a patchy or asymmetric appearance. Examples of mosaicism syndromes include [[Pallister-Killian syndrome]] and [[Hypomelanosis of Ito]].<ref name=Avery/>

=== Mosaicism in malignant transformation ===
[[File:Two hit malignant transformation with chromosome loss.png|700px|thumb| '''Loss of a tumor suppressor gene locus according to the two-hit model''': 
In the first hit, the tumor suppressor gene on one of the two chromosomes is affected by a mutation that makes the gene product non-functional. This mutation may arise spontaneously as a DNA replication error or may be induced by a DNA damaging agent. The second hit removes the remaining wild-type chromosome, for example through a '''mitotic nondisjunction''' event. There are several other potential mechanisms for each of the two steps, for example an additional mutation, an unbalanced translocation, or a gene deletion by recombination. As a result of the double lesion, the cell may become malignant because it is no longer able to express the tumor suppressor protein.]]

Development of cancer often involves multiple alterations of the cellular genome ([[Knudson hypothesis]]). Human [[retinoblastoma]] is a well studied example of a cancer type where mitotic nondisjunction can contribute to malignant transformation: Mutations of the RB1 gene, which is located on chromosome 13 and encodes the tumor suppressor [[retinoblastoma protein]], can be detected by cytogenetic analysis in many cases of retinoblastoma. Mutations of the RB1 locus in one copy of chromosome 13 are sometimes accompanied by loss of the other wild-type chromosome 13 through mitotic nondisjunction. By this combination of lesions, affected cells completely lose expression of functioning tumor suppressor protein.<ref name = Scriver />

==Diagnosis==

===Preimplantation genetic diagnosis===
[[Preimplantation genetic diagnosis|Pre-implantation genetic diagnosis (PGD or PIGD)]] is a technique used to identify genetically normal [[embryo]]s and is useful for couples who have a family history of genetic disorders. This is an option for people choosing to procreate through [[In vitro fertilisation|IVF]]. PGD is considered difficult due to it being both time consuming and having success rates only comparable to routine IVF.<ref>{{cite journal|last=Harper|first=JC|author2=Harton G |title=The use of arrays in preimplantation genetic diagnosis and screening|journal=Fertil Steril|volume=94|issue=4|pages=1173–1177|doi=10.1016/j.fertnstert.2010.04.064|pmid=20579641|year=2010|doi-access=free}}</ref>

===Karyotyping===
[[Karyotype|Karyotyping]] involves performing an [[amniocentesis]] in order to study the cells of an unborn fetus during metaphase 1. [[Light microscopy]] can be used to visually determine if aneuploidy is an issue.<ref>{{cite web|title=Karyotyping|url=https://www.medlineplus.gov/ency/article/003935.htm|publisher=National Institute of Health|access-date=7 May 2014}}</ref>

===Polar body diagnosis===
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696746/ Polar body diagnosis] (PBD) can be used to detect maternally derived chromosomal aneuploidies as well as translocations in oocytes. The advantage of PBD over PGD is that it can be accomplished in a short amount of time. This is accomplished through zona drilling or laser drilling.<ref>{{cite journal|last=Montag|first=M|author2=van der Ven, K|author3=Rösing, B|author4=van der Ven, H|title=Polar body biopsy: a viable alternative to preimplantation genetic diagnosis and screening|journal=Reproductive Biomedicine Online|year=2009|volume=18|issue=Suppl 1|pages=6–11|pmid=19281658|doi=10.1016/s1472-6483(10)60109-5}}</ref>

===Blastomere biopsy===
[[Blastomere]] biopsy is a technique in which blastomeres are removed from the [[zona pellucida]]. It is commonly used to detect aneuploidy.<ref>{{cite journal|last=Parnes|first=YM|title=RCT controversy.|journal=Journal of Obstetric, Gynecologic, & Neonatal Nursing|date=Mar–Apr 1989|volume=18|issue=2|page=90|pmid=2709181|doi=10.1111/j.1552-6909.1989.tb00470.x}}</ref> Genetic analysis is conducted once the procedure is complete. Additional studies are needed to assess the risk associated with the procedure.<ref>{{cite journal|last=Yu|first=Y|author2=Zhao, Y |author3=Li, R |author4=Li, L |author5=Zhao, H |author6=Li, M |author7=Sha, J |author8=Zhou, Q |author9= Qiao, J |title=Assessment of the risk of blastomere biopsy during preimplantation genetic diagnosis in a mouse model: reducing female ovary function with an increase in age by proteomics method.|journal=Journal of Proteome Research|date=Dec 6, 2013|volume=12|issue=12|pages=5475–86|pmid=24156634 |doi=10.1021/pr400366j}}</ref>

==Lifestyle/environmental hazards==
Exposure of spermatozoa to lifestyle, environmental and/or occupational hazards may increase the risk of aneuploidy. Cigarette smoke is a known [[aneugen]] ([[aneuploidy]] inducing agent). It is associated with increases in aneuploidy ranging from 1.5 to 3.0-fold.<ref name="pmid11468778">{{cite journal |vauthors=Shi Q, Ko E, Barclay L, Hoang T, Rademaker A, Martin R |title=Cigarette smoking and aneuploidy in human sperm |journal=Mol. Reprod. Dev. |volume=59 |issue=4 |pages=417–21 |year=2001 |pmid=11468778 |doi=10.1002/mrd.1048 |s2cid=35230655 }}</ref><ref name="pmid9797104">{{cite journal |vauthors=Rubes J, Lowe X, Moore D, Perreault S, Slott V, Evenson D, Selevan SG, Wyrobek AJ |title=Smoking cigarettes is associated with increased sperm disomy in teenage men |journal=Fertil. Steril. |volume=70 |issue=4 |pages=715–23 |year=1998 |pmid=9797104 |doi= 10.1016/S0015-0282(98)00261-1|doi-access=free }}</ref> Other studies indicate factors such as alcohol consumption,<ref name="pmid21273273">{{cite journal |vauthors=Benassi-Evans B, Fenech M |title=Chronic alcohol exposure induces genome damage measured using the cytokinesis-block micronucleus cytome assay and aneuploidy in human B lymphoblastoid cell lines |journal=Mutagenesis |volume=26 |issue=3 |pages=421–9 |year=2011 |pmid=21273273 |doi=10.1093/mutage/geq110 |doi-access=free }}</ref> occupational exposure to [[benzene]],<ref name="pmid24571325">{{cite journal |vauthors=McHale CM, Smith MT, Zhang L |title=Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human |journal=Ann. N. Y. Acad. Sci. |volume=1310 |pages=74–83 |year=2014 |issue=1 |pmid=24571325 |pmc=3978411 |doi=10.1111/nyas.12382 |bibcode=2014NYASA1310...74M }}</ref> and exposure to the insecticides [[fenvalerate]]<ref name="pmid15363581">{{cite journal |vauthors=Xia Y, Bian Q, Xu L, Cheng S, Song L, Liu J, Wu W, Wang S, Wang X |title=Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate |journal=Toxicology |volume=203 |issue=1–3 |pages=49–60 |year=2004 |pmid=15363581 |doi=10.1016/j.tox.2004.05.018 |s2cid=36073841 }}</ref> and [[carbaryl]]<ref name="pmid15615886">{{cite journal |vauthors=Xia Y, Cheng S, Bian Q, Xu L, Collins MD, Chang HC, Song L, Liu J, Wang S, Wang X |title=Genotoxic effects on spermatozoa of carbaryl-exposed workers |journal=Toxicol. Sci. |volume=85 |issue=1 |pages=615–23 |year=2005 |pmid=15615886 |doi=10.1093/toxsci/kfi066 |doi-access=free }}</ref> also increase aneuploidy.

== References ==
{{Reflist}}

[[Category:Genetics]]

Nondisjunction - История изменений

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